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/Antineoplastic antibiotic isolated from the culture of the fungus Streptomyces caespitosus. Inhibits DNA synthesis at high concentrations, inhibits protein synthesis and RNA. Most active and Gi S- phases of mitosis. After enzymatic activation in the tissues it acts as a bi- or trifunctional alkylating drug. It has a relatively weak immunosuppressive activity. Like other cytotoxic …